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Synthesis and Characterization of a Marine Collagen-Chitosan/HA-SiO2-Based Bioink
Andrea Cazares-Tafoya1, Marcos Valenzuela-Reyes1, Solange Rivera-Manrique2
1Department of Electrical Engineering and Computer Science, Autonomous University of Ciudad Juárez, Cd. Juárez 32320, Mexico.
Gels (Basel, Switzerland)
|March 27, 2026
Summary
This study developed a novel bioink from marine collagen, chitosan, and silica-doped hydroxyapatite for 3D bioprinting. While showing promise for scaffold fabrication, its printability requires further optimization.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- 3D Bioprinting
Background:
- Developing advanced bioinks is crucial for creating functional tissue scaffolds.
- Marine collagen, chitosan, and hydroxyapatite offer promising properties for biomaterial applications.
Purpose of the Study:
- To synthesize and characterize a novel bioink for extrusion-based 3D bioprinting.
- To evaluate the physicochemical, microstructural, and rheological properties of the bioink.
- To assess the preliminary printability of the bioink for scaffold fabrication.
Main Methods:
- Fourier-transform infrared (FTIR) spectroscopy for chemical characterization.
- Thermogravimetric analysis (TGA) for thermal stability assessment.
- Scanning electron microscopy (SEM) for microstructure analysis.
- Rheological measurements to determine flow behavior.
- 3D bioprinting process evaluation using a BIO X printer.
Main Results:
- FTIR confirmed the presence of collagen, chitosan, and HA-SiO2 components.
- TGA indicated thermal stability suitable for bioprinting processes.
- SEM revealed a porous, interconnected microstructure.
- Rheology showed shear-thinning behavior and elastic dominance, suitable for extrusion.
- Preliminary 3D printing demonstrated shape retention but limited filament continuity.
Conclusions:
- The developed bioink formulation is a viable starting point for fabricating 3D scaffolds.
- Further optimization is needed to improve filament continuity and printing precision.
- The combination of marine collagen, chitosan, and HA-SiO2 shows potential for tissue engineering applications.
