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Amaranth Oil for Dermatologic Conditions: Inflammation Control and Cytotoxicity Assessment in Skin-Related Cell

Paweł Paśko1, Agnieszka Galanty2, Ewelina Prochownik1

  • 1Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, 30-688 Kraków, Poland.

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Summary

Amaranth oil (AMO) and rose oil (AMOR) formulations show topical safety. AMOR demonstrates superior anti-inflammatory and melanoma cell-killing effects, supporting amaranth oil

Keywords:
amaranth oilcytotoxicityfood for skinhuman serum albumin bindinginflammationrose oilskinskin cancertopical use

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Area of Science:

  • Dermatology and Cosmetology
  • Pharmacology and Toxicology
  • Natural Product Chemistry

Background:

  • Amaranth oil (AMO) and its topical formulations are explored for skin health benefits.
  • Understanding the anti-inflammatory and cytotoxic properties of AMO and rose oil (AMOR) is crucial for therapeutic applications.

Purpose of the Study:

  • To evaluate the anti-inflammatory and cytotoxic effects of amaranth oil (AMO) and a rose oil-enriched formulation (AMOR) on skin-relevant models.
  • To assess the safety and selectivity of these oils against normal keratinocytes and melanoma cell lines.

Main Methods:

  • Utilized LPS-stimulated macrophages and TNF-α/IFN-γ-stimulated HaCaT keratinocytes for inflammation assessment.
  • Performed cytotoxicity and selectivity tests on human HaCaT keratinocytes and melanoma cell lines (A375, HTB140).
  • Employed GC-MS and FTIR for compositional analysis, identifying key bioactive compounds like squalene and fatty acids.

Main Results:

  • AMOR exhibited higher polyphenol and palmitic acid content compared to AMO.
  • AMOR demonstrated significantly greater reduction in inflammatory markers (IL-6, IL-1β, TNF-α) in both tested models.
  • Both oils were safe on normal keratinocytes but showed selective cytotoxicity against melanoma cells, with AMOR being more potent (IC50 values provided).

Conclusions:

  • Amaranth oil (AMO) and its rose oil-enriched formulation (AMOR) possess promising topical safety profiles.
  • AMOR offers enhanced anti-inflammatory and selective cytotoxic effects against melanoma cells due to its enriched composition.
  • This study highlights the therapeutic potential of amaranth oil, particularly when combined with complementary essential oils, for various skin conditions.