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A Smartphone-Driven Acoustic Platform for Non-Invasive Modulation of Cellular Behavior in Microfluidic Channels.

Giulia Valenti1, Emanuela Cutuli2, Francesca Guarino1

  • 1Department of Biomedical and Biotechnological Science, University of Catania, Via Santa Sofia 89, 95123 Catania, Italy.

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Summary

This study introduces a low-cost method using smartphone audio to create acoustic-mechanical perturbations (AMPs) for precise cell manipulation in microfluidics. The technique allows for label-free control of cell behavior, distinguishing between biological cells and inert particles.

Keywords:
acousto-mechanical perturbationimage processingmicrofluidics

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Area of Science:

  • Biophysics
  • Microfluidics
  • Acoustic manipulation

Background:

  • Passive cell manipulation in microfluidics is vital for biomedical applications.
  • Precise, low-cost, and non-invasive cell control remains a challenge.

Purpose of the Study:

  • To develop a novel method for modulating cell arrangement and behavior using controlled acousto-mechanical perturbations (AMPs).
  • To demonstrate label-free cellular manipulation via acoustic actuation in microchannels.

Main Methods:

  • Coupling a smartphone audio speaker to a microfluidic device to generate AMPs.
  • Applying acoustic signals to induce mechanical vibrations and interact with hydrodynamic flows.
  • Experimenting with yeast cells and silica beads under varying flow conditions.

Main Results:

  • Acoustic stimulation induced periodic flow dynamics and synchronized responses in yeast cells.
  • Distinct dynamical responses were observed between deformable biological cells and rigid inert particles.
  • Frequency-domain analysis confirmed synchronization with acoustic protocols and identified higher-frequency components.

Conclusions:

  • Simple, low-cost acoustic actuation enables label-free manipulation of cells in microfluidics.
  • The proposed platform offers a versatile, non-invasive, and accessible approach for cell control.
  • This method effectively differentiates cellular responses based on mechanical properties.