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A STAT1-Knockout Mouse Model for Chapare Virus Infection and Pathogenesis.

Stephanie R Monticelli1,2, Ana I Kuehne1, Thomas G Batchelor1,3

  • 1Viral Immunology Branch, Virology Division, United States Army Medical Research Institute of Infectious Disease, Ft. Detrick, Frederick, MD 21702, USA.

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|March 28, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a lethal mouse model for Chapare virus (CHAPV) infection. This STAT1-deficient mouse model mimics human Chapare hemorrhagic fever (CHHF) disease, aiding future research on this dangerous arenavirus.

Keywords:
Chapare hemorrhagic feverChapare virusSTAT1 knockoutarenavirusmouse model

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Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Chapare virus (CHAPV) causes Chapare hemorrhagic fever (CHHF) in Bolivia, with high fatality rates and human-to-human transmission.
  • The pathogenesis of CHAPV infection remains poorly understood, hindering the development of treatments and vaccines.
  • A lack of suitable animal models limits research into CHAPV and related arenaviruses.

Purpose of the Study:

  • To investigate the susceptibility of signal transducer and activator of transcription 1-deficient (STAT1-/-) mice to CHAPV infection.
  • To establish a small-animal model that recapitulates key features of human CHAPV disease.
  • To generate a mouse-adapted CHAPV variant for further study.

Main Methods:

  • STAT1-/- mice were challenged with CHAPV.
  • Disease progression, viral load, and tissue tropism were monitored.
  • CHAPV was adapted in the brains of STAT1-/- mice to create a lethal variant.

Main Results:

  • CHAPV challenge caused partial lethality in STAT1-/- mice with a biphasic disease course.
  • Initial viral replication occurred in the spleen and liver, followed by central nervous system (CNS) involvement.
  • A mouse-adapted CHAPV variant demonstrated increased virulence and a similar biphasic disease pattern.

Conclusions:

  • STAT1-/- mice provide a valuable small-animal model for studying CHAPV infection and Chapare hemorrhagic fever.
  • This model recapitulates critical aspects of human CHAPV disease, including biphasic pathology and CNS tropism.
  • The developed mouse-adapted CHAPV facilitates further research into arenavirus pathogenesis and therapeutic strategies.