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Electroactive Dual-Drug Hydrogel-PLA Conduit for Nerve Regeneration.

Kebi Li1, Xiaopei Wu1, Peijun Xiong1

  • 1School of Chemistry, Chemical Engineering and Life Sciences, State Key Laboratory of Advanced Glass Materials, Wuhan University of Technology, Wuhan, China.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|March 30, 2026
PubMed
Summary

A new composite nerve conduit enhances peripheral nerve regeneration by combining a collagen-grafted polylactic acid scaffold with a conductive, anti-inflammatory hydrogel. This dual-drug delivery system shows promise for repairing nerve injuries.

Keywords:
hydrogelnerve regenerationperipheral nerve injurypolylactic acid

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Neuroscience

Background:

  • Peripheral nerve injury (PNI) poses significant clinical challenges, with autologous nerve grafting having limitations.
  • Developing advanced nerve conduits is crucial for improving peripheral nerve regeneration outcomes.

Purpose of the Study:

  • To create a multifunctional composite nerve conduit for enhanced peripheral nerve regeneration.
  • To integrate a conductive and anti-inflammatory hydrogel with a collagen-grafted polylactic acid (PLA) scaffold.
  • To develop a dual-drug delivery system for sustained release of nerve growth factor (NGF) and anti-inflammatory agents.

Main Methods:

  • Fabricated a hydrogel via cross-linking carboxymethyl chitosan (CMCS) and sodium carboxymethyl cellulose (CMC-Na), incorporating polyaniline (PANI) for conductivity and rhein (RH) for anti-inflammatory effects.
  • Modified a PLA electrospun scaffold with collagen and loaded it with NGF.
  • Characterized the composite conduit's hydrophilicity, mechanical properties, degradation, porosity, and electrical conductivity.
  • Evaluated in vitro effects on Schwann cells and neurons, and in vivo nerve regeneration in a rat sciatic nerve defect model.

Main Results:

  • The modified conduit showed improved hydrophilicity and mechanical strength.
  • Sustained release of NGF and RH was achieved over 30 days, with stable degradation over 72 days.
  • The composite conduit exhibited significant electrical conductivity (3.27 mS/cm) and enhanced Schwann cell adhesion, neurite outgrowth, and neuronal differentiation in vitro.
  • In vivo studies demonstrated significantly accelerated nerve regeneration in a rat sciatic nerve model.

Conclusions:

  • The developed electrically responsive, dual-drug-loaded hydrogel-filled nerve conduit is a promising alternative to autologous nerve grafts.
  • This composite conduit effectively promotes peripheral nerve regeneration through its unique structural and functional properties.
  • The study highlights the potential of combining conductive biomaterials with controlled drug delivery for advanced nerve repair strategies.