Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

2.8K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Network meta-analysis of first-line R-CHOP-based regimens in MYC/BCL2 double-expressor diffuse large B-cell lymphoma.

Frontiers in immunology·2026
Same author

Human CD24<sup>+</sup> dental papilla cells are competent seed cells for dentin-pulp regeneration via BMP2/SIRT1 axis.

Nature communications·2026
Same author

Propensity-matched study of liposomal doxorubicin vs. doxorubicin in first-line DLBCL treatment: efficacy and safety.

Frontiers in medicine·2026
Same author

Identification of GLDN<sup>+</sup> odontogenic stem cells as crucial for human tooth development and regeneration.

International journal of oral science·2026
Same author

Myokines in Aging: A Multi-Organ Network Perspective.

Aging and disease·2025
Same author

TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway.

International journal of molecular medicine·2025

Related Experiment Video

Updated: Mar 31, 2026

Author Spotlight: Understanding Dynamic Cellular Behaviors in Adult Mouse Dental Tissue Renewal and Repairment
07:37

Author Spotlight: Understanding Dynamic Cellular Behaviors in Adult Mouse Dental Tissue Renewal and Repairment

Published on: October 27, 2023

2.2K

Resolving tooth development at single-cell resolution: advancing dental regeneration.

Chengcheng Liao1,2,3, Jun Cai1,2, Yanmei Liu1,2

  • 1Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.

Frontiers in Cell and Developmental Biology
|March 30, 2026
PubMed
Summary
This summary is machine-generated.

Single-cell transcriptomics reveals cellular details of tooth development, advancing our understanding of organogenesis. These findings offer new strategies for dental tissue regeneration.

Keywords:
dentinenamelregenerative medicinesingle-cell sequencingtooth development

More Related Videos

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

4.3K
Rapid Isolation of Single Cells from Mouse and Human Teeth
06:09

Rapid Isolation of Single Cells from Mouse and Human Teeth

Published on: October 28, 2021

4.4K

Related Experiment Videos

Last Updated: Mar 31, 2026

Author Spotlight: Understanding Dynamic Cellular Behaviors in Adult Mouse Dental Tissue Renewal and Repairment
07:37

Author Spotlight: Understanding Dynamic Cellular Behaviors in Adult Mouse Dental Tissue Renewal and Repairment

Published on: October 27, 2023

2.2K
Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

4.3K
Rapid Isolation of Single Cells from Mouse and Human Teeth
06:09

Rapid Isolation of Single Cells from Mouse and Human Teeth

Published on: October 28, 2021

4.4K

Area of Science:

  • Developmental Biology
  • Genomics
  • Regenerative Medicine

Background:

  • Tooth development is a complex, sequential process crucial for understanding organ formation.
  • Single-cell transcriptomics has emerged as a powerful tool for analyzing cellular heterogeneity and developmental processes.

Purpose of the Study:

  • To elucidate the cellular and molecular mechanisms underlying tooth development using single-cell transcriptomics.
  • To enhance the understanding of odontogenesis and its potential for dental tissue regeneration.

Main Methods:

  • Single-cell RNA sequencing (scRNA-seq) applied to mouse and human tooth germ samples.
  • Bioinformatic analysis to identify cell types, lineage trajectories, and signaling pathways.
  • Comparative analysis across species to identify conserved and divergent developmental mechanisms.

Main Results:

  • Detailed mapping of cellular heterogeneity during tooth development.
  • Identification of key signaling pathways regulating cell fate decisions and differentiation.
  • Uncovered distinct lineage trajectories of dental cell types.

Conclusions:

  • Single-cell transcriptomics provides unprecedented resolution into tooth organogenesis.
  • Understanding these molecular networks is foundational for advancing dental tissue regeneration strategies.
  • This research enhances knowledge of developmental biology and informs future regenerative approaches.