Metal-polyphenol network-based multifunctional materials for tumor therapy: Intrinsic properties, advances, and...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Oncology

Background:

• Metal-polyphenol networks (MPNs) are emerging nano-biomaterials with tunable properties.
• Their potential in tumor diagnosis and therapy is significant due to multifunctionality and biocompatibility.

Purpose of the Study:

• To systematically review MPN synthesis, properties, and applications in tumor theranostics.
• To analyze MPN-based biomaterials and their therapeutic mechanisms against cancer.
• To evaluate clinical translation challenges and future perspectives for MPNs in precise tumor treatment.

Main Methods:

• Exploration of one-step and multi-step MPN synthesis strategies.
• Analysis of MPN physicochemical properties and drug-loading capabilities.
• Review of integrated therapeutic modalities (chemotherapy, PTT, PDT, CDT) and targeted delivery systems.

Main Results:

• MPNs offer precise control over size, morphology, and drug loading.
• MPNs can integrate multiple therapies and enable tumor-specific targeting.
• Surface modification allows for multimodal imaging and real-time monitoring.

Conclusions:

• MPNs demonstrate excellent biocompatibility and biodegradability for biomedical use.
• MPNs hold transformative potential for advancing tumor theranostics.
• Further research and development are crucial for clinical translation of MPN-based platforms.