Anshen Jieyu Decoction: A Promising Remedy for Depression via AKT/mTOR Pathway Modulation in CUMS Rats

Area of Science:

• Neuroscience
• Pharmacology
• Stress Research

Background:

• Chronic unpredictable mild stress (CUMS) induces behavioral and physiological changes mimicking depression.
• The hypothalamic-pituitary-adrenal (HPA) axis and AKT/mTOR signaling pathways are implicated in stress responses and neuronal health.

Purpose of the Study:

• To evaluate the therapeutic effects of An Shen Jie Yu Tang (ASJYD) on CUMS-induced rat models.
• To investigate ASJYD's impact on hippocampal morphology, HPA axis activity, and AKT/mTOR pathway modulation.

Main Methods:

• Rats were subjected to CUMS, with one group receiving ASJYD treatment.
• Behavioral tests, serum hormone analysis (ACTH, CORT), Western blot for p-AKT/p-mTOR, and histological examination of the hippocampus were performed.

Main Results:

• ASJYD treatment significantly improved CUMS-induced behavioral impairments.
• ASJYD reduced serum ACTH and corticosterone levels.
• ASJYD increased hippocampal p-AKT/p-mTOR expression and protected neuronal morphology.

Conclusions:

• ASJYD demonstrates antidepressant-like effects in a rat model of chronic stress.
• ASJYD normalizes HPA axis activity and enhances AKT/mTOR signaling.
• ASJYD offers neuroprotective benefits against stress-induced hippocampal damage.