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Updated: Apr 2, 2026

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse
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Severe Aortic Regurgitation in Osteogenesis Imperfecta Complicated by Mediastinal Hematoma

Atsuki Yamamoto1, Tatsuya Kitagawa1, Yusuke Hirao1

  • 1Division of Cardiovascular Medicine, Ako City Hospital, Ako, Hyogo, Japan.

JACC. Case Reports
|April 1, 2026
PubMed

Insights

Osteogenesis imperfecta (OI) can cause aortic regurgitation (AR) and bleeding complications, even with normal coagulation tests. This case highlights intrinsic leaflet fragility in OI contributing to AR and emphasizes careful perioperative management.

Area of Science:

  • Cardiology
  • Genetics
  • Pathology

Background:

  • Osteogenesis imperfecta (OI) is a heritable type I collagen disorder.
  • OI is associated with aortic regurgitation (AR) and increased perioperative bleeding risk.
  • Routine coagulation tests may not detect bleeding risks in OI patients.
Abstract

Keywords:
aortic valveechocardiographyvalve replacement

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