Related Experiment Video
Updated: Apr 3, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
[Primary malignant bone tumours-part 1]
1Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Augsburg, Stenglinstraße 2, 86156, Augsburg, Deutschland. thomas.grieser@gmx.com.
Abstract:
Primary malignant bone tumours are rare (about 0.2% of all malignancies) whereby-according to age-both osteosarcoma and Ewing's sarcoma are the most frequent bone sarcomas in children and adolescents. Both sarcomas are highly-malignant tumours with poor prognosis (Ewing's sarcoma) in particular when metastasized (osteosarcoma). There is a broad diagnostic armamentarium available, allowing precise detection of such tumours. However, alertness and familiarity of (early) radiological signs (such as periosteal reactions) are prerequisites to arouse suspicion. Radiological methods (plain radiography, magnetic resonance imaging [MRI], computed tomography [CT], ultrasonography) will be discussed regarding their pathomorphological clues. Likewise, both use and significance of more advanced imaging modalities (dual-energy CT, photon-counting CT; the Dixon technique and MRI with ultrashort time-to-echo [TE] sequences) are reviewed.
Related Concept Videos
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Bone Cells and Tissue
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancers Originate from Somatic Mutations in a Single Cell

