Oncologic Outcomes following Resection for Primary Chest Wall Tumors: Review of Multi-institutional Database Studies

Primary chest wall tumors are rare malignant neoplasms, most commonly sarcomas, for which complete surgical resection is the main curative therapy. Surgical resection conferred substantial survival benefit compared with nonoperative management. Histology-specific differences were notable, with chondrosarcoma demonstrating favorable long-term survival and high-grade soft tissue sarcomas having poorer prognosis. Adjuvant radiotherapy improved local control in high-risk soft tissue sarcomas, while systemic therapy was essential for chemosensitive histologies. In conclusion, multi-institutional data underscore the central role of complete surgical resection in achieving optimal oncologic outcomes for primary chest wall tumors, with adjunctive therapy reserved for selected high-risk patients.