Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.9K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.9K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

6.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
6.0K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

6.4K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
6.4K
Stem Cell Culture01:17

Stem Cell Culture

6.6K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.6K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

19.6K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
19.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emerging Role of AI in Gastroenterology and Hepatology: Revolutionizing Medical Device-Assisted Diagnosis.

Current pharmaceutical design·2026
Same author

Identification of condition-specific optimal reference genes for qPCR data normalisation in pink bollworm Pectinophora gossypiella (Saunders).

Molecular biology reports·2026
Same author

Engineering bioinspired pH-responsive hydrogels for smart wound repair.

Nanoscale·2026
Same author

Targeting mtDNA to Modulate Mitochondrial Dysfunction in Neurodegenerative Diseases.

Molecular neurobiology·2026
Same author

Smart sensing the spectrum: cutting-edge biosensor and biomarker approaches for early autism detection.

Metabolic brain disease·2026
Same author

Hormonal Imbalance and Gut Dysbiosis: Emerging Perspectives in Women's Health.

Probiotics and antimicrobial proteins·2026

Related Experiment Video

Updated: Apr 5, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.4K

ROS-associated metabolic disorders: Molecular mechanism and stem cell therapy.

Biplab Debnath1, Joy Das2, Utpal Bhui3

  • 1Department of Pharmaceutical Technology, Bharat Technology, Uluberia, West Bengal 711316, India.

Pathology, Research and Practice
|April 3, 2026
PubMed
Summary
This summary is machine-generated.

Reactive oxygen species (ROS) contribute to metabolic disorders by causing oxidative stress. Stem cell (SC) therapy, combined with antioxidants, shows promise in managing these ROS-related conditions.

Keywords:
Metabolic disordersMitochondrial dysfunctionOxidative stressReactive oxygen speciesStem cell therapy

More Related Videos

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia
09:44

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia

Published on: September 5, 2019

7.9K
Analysis of Hematopoietic Stem Progenitor Cell Metabolism
12:20

Analysis of Hematopoietic Stem Progenitor Cell Metabolism

Published on: November 9, 2019

7.4K

Related Experiment Videos

Last Updated: Apr 5, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.4K
Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia
09:44

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia

Published on: September 5, 2019

7.9K
Analysis of Hematopoietic Stem Progenitor Cell Metabolism
12:20

Analysis of Hematopoietic Stem Progenitor Cell Metabolism

Published on: November 9, 2019

7.4K

Area of Science:

  • Biochemistry
  • Cellular Biology
  • Endocrinology

Background:

  • Metabolic disorders encompass conditions like obesity, diabetes, and cardiovascular diseases, often stemming from imbalanced energy regulation and cellular homeostasis.
  • Reactive oxygen species (ROS), byproducts of metabolism, are increasingly implicated in the early stages of metabolic diseases.
  • Excessive ROS leads to oxidative stress, damaging cells and disrupting crucial metabolic pathways like lipid metabolism and insulin signaling.

Purpose of the Study:

  • To review the role of ROS in the pathogenesis of metabolic disorders.
  • To explore the potential of stem cell (SC) therapy in mitigating oxidative stress in metabolic diseases.
  • To discuss the combined application of SCs and antioxidants for treating metabolic disorders.

Main Methods:

  • Literature review focusing on the involvement of ROS in metabolic disorders.
  • Analysis of current research on stem cell applications for metabolic conditions.
  • Examination of studies investigating antioxidant therapies in conjunction with stem cells.

Main Results:

  • ROS significantly contribute to cellular damage and dysfunction in metabolic disorders.
  • Stem cell therapy presents a promising avenue for managing metabolic disorders.
  • Antioxidant strategies alongside SCs may effectively counteract ROS-induced damage.

Conclusions:

  • Oxidative stress driven by ROS is a key factor in metabolic disorder development.
  • Stem cell therapy offers a novel therapeutic strategy for metabolic diseases.
  • Combining stem cells with antioxidants holds potential for enhanced treatment outcomes.