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Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

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Related Experiment Video

Updated: Jun 7, 2026

Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters

Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters

Published on: June 23, 2023

Less is more: Reducing zinc to boost stem cell-derived islet function and survival.

Hazem Ibrahim¹, Diego Balboa¹, Timo Otonkoski²

¹Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.

|April 3, 2026

Summary

This summary is machine-generated.

Inhibition of zinc transport in stem cell-derived islets surprisingly boosts beta cell function. This approach enhances islet maturation, resilience to low oxygen, and improves transplant outcomes.

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Isolated Pancreatic Islet Treatment and Apoptosis Measurement

Isolated Pancreatic Islet Treatment and Apoptosis Measurement

Published on: May 2, 2025

Area of Science:

Endocrinology
Metabolic Research
Stem Cell Biology

Background:

Zinc is crucial for insulin packaging within secretory granules.
Reduced zinc transporter activity in beta cells paradoxically improves their function.

Purpose of the Study:

To investigate the effects of pharmacologic inhibition of zinc transport on stem cell-derived islets.
To determine if modulating zinc transport can enhance beta cell function and therapeutic potential.

Main Methods:

Utilized stem cell-derived islets.
Applied pharmacologic inhibition of zinc transport.
Assessed key markers of beta cell function and therapeutic efficacy.

Main Results:

Inhibition of zinc transport activated AMP-activated protein kinase (AMPK) signaling.
Enhanced beta cell maturation and improved resistance to hypoxia.
Increased vascular endothelial growth factor A (VEGFA) expression.
Improved performance of islet grafts in vivo.

Conclusions:

Pharmacologic inhibition of zinc transport is a promising strategy to enhance stem cell-derived islet function and therapeutic potential.
Modulating zinc homeostasis offers a novel approach for improving beta cell replacement therapies.