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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
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Liposomes: A breakthrough in advanced drug delivery systems
Xunan Zhang1, Wenjie Liu2, Hongtao Chu2
1College of Chemistry and Chemical Engineering. Qiqihar University, Qiqihar 161006, China; Heilongjiang Industrial Hemp Processing Technology Innovation Center, Qiqihar University, Qiqihar 161006, China.
Advances in Colloid and Interface Science
|April 5, 2026
Summary
Liposomes, versatile drug carriers, offer enhanced efficacy and reduced toxicity for various treatments. This review details their cellular interactions, delivery routes, and applications in anticancer, antibacterial, and antiviral therapies.
Area of Science:
- Nanotechnology and Pharmaceutical Sciences
- Biomedical Engineering
- Drug Delivery Systems
Background:
- Liposomes are recognized for their phospholipid bilayer structure, biocompatibility, and ease of preparation.
- Extensive research has focused on liposome-based systems to reduce drug toxicity and prolong therapeutic efficacy.
- Liposomal encapsulation is established for small molecule therapies and macromolecular biopharmaceuticals.
Purpose of the Study:
- To review the mechanisms of liposomal drug carrier-cell interactions.
- To outline the delivery routes of liposomes to target disease sites.
- To summarize the applications of liposomal drug carriers in various therapeutic areas.
Main Methods:
- Comprehensive literature review of liposome research and clinical applications.
- Analysis of mechanisms governing liposome-cell interactions.
- Evaluation of liposome delivery routes and therapeutic outcomes.
Main Results:
- Liposomes demonstrate broad applicability in anticancer, antibacterial, and antiviral treatments.
- Numerous FDA-approved liposomal therapies and ongoing clinical trials highlight their therapeutic potential.
- Liposomal drug delivery systems are effective for both hydrophilic and hydrophobic compounds.
Conclusions:
- Liposomes represent a pivotal drug delivery system with significant therapeutic advantages.
- Further research and development of liposomal formulations are valuable for advancing medical treatments.
- Understanding liposome-cell interactions and delivery is key to optimizing their clinical use.
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