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Hydrogels in regenerative wound therapy: A journey from basic polymers to smart platforms
Nikita Sharma1, Snigdha Bhardwaj1, Kandasamy Nagarajan1
1Department of Pharmacy, Krishna Institute of Engineering & Technology (KIET), Ghaziabad, Delhi-NCR, Uttar Pradesh, India.
Annales Pharmaceutiques Francaises
|April 5, 2026
Summary
Advanced hydrogels, incorporating growth factors or nanostructures, significantly accelerate wound healing. These gel-based wound coverings offer tunable properties and therapeutic integration for improved tissue repair.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Hydrogels mimic the natural extracellular matrix.
- Hydrogels maintain a moist wound environment, crucial for tissue repair.
- Their structural similarity to the ECM makes them ideal for wound dressings.
Purpose of the Study:
- To review advancements in gel-based wound coverings.
- To focus on structural composition and functional modifications.
- To assess the integration of bioactive agents and polymers in hydrogels.
Main Methods:
- Systematic literature search across major scientific databases (Scopus, PubMed, ScienceDirect, Web of Science).
- Keywords included hydrogels, wound healing, and bioactive nanomaterials.
- Analysis of studies published over the last fifteen years.
Main Results:
- Multifunctional hydrogels show accelerated wound repair.
- Hydrogels loaded with growth factors, antibacterial agents, or nanostructures are particularly effective.
- These advanced materials enhance the healing process.
Conclusions:
- Hydrogel systems possess significant potential for future wound care.
- Tunable properties allow for customized therapeutic delivery.
- Integration of therapeutics within hydrogels enhances wound treatment efficacy.
