Related Experiment Video
Updated: Jul 3, 2026

05:44
Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
Published on: November 5, 2020
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Correction: Vimentin expression as a prognostic marker in pancreatic cancer: a systematic review and meta-analysis
Oana-Iulia Cretu1, Cristian Virgil Lungulescu2, Manuel Gentiluomo3
1Department of Pathology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Frontiers in Medicine
|April 6, 2026
Abstract:
[This corrects the article DOI: 10.3389/fmed.2026.1742644.].
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

