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Updated: Apr 8, 2026

Multi-Modal Home Sleep Monitoring in Older Adults
Published on: January 26, 2019
Association of CLOCK rs1801260 Polymorphism with Sleep Quality in Residents of the Far North
D G Gubin1,2, S N Kolomeychuk3,4, M F Borisenkov5
1Tyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia. dgubin@mai.ru.
Abstract:
In a longitudinal study of permanent Arctic residents, an actigraphic analysis of sleep quality indicators across different seasons revealed no significant overall seasonal differences in sleep efficiency (p = 0.487). However, TT homozygotes for the CLOCK gene rs1801260 polymorphism the exhibited lower sleep efficiency, particularly in spring and summer. Multiple linear regression, incorporating categorical covariates including rs1801260 polymorphism, sex, season, indigenous status, age, and body mass index, identified the TT genotype as the sole significant predictor of sleep efficiency (β = -0.215; p = 0.029), confirming its association with poorer sleep quality.
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