Neutrophils in Rat Dorsal Root Ganglion during Acute Systemic Inflammation
1Institute of Experimental Medicine, St. Petersburg, Russia. koloselena1984@yandex.ru.
Bulletin of Experimental Biology and Medicine
|April 7, 2026
Summary
Systemic inflammation causes neutrophils to enter the dorsal root ganglia (DRG) in rats. This immune cell infiltration occurs in both neuronal cell body and neurite-rich areas of the DRG.
Area of Science:
- Neuroscience
- Immunology
- Pain Research
Background:
- Systemic inflammation is linked to neuropathic pain development.
- The role of immune cells, particularly neutrophils, in the dorsal root ganglia (DRG) during systemic inflammation remains unclear.
Purpose of the Study:
- To investigate the distribution and localization of neutrophils within the rat DRG during acute systemic inflammation.
- To understand how systemic inflammation affects immune cell presence in the DRG.
Main Methods:
- Experimental acute systemic inflammation was induced in rats via bacterial endotoxin injection.
- Neutrophil presence and location in the DRG were examined.
Main Results:
- Systemic inflammation led to increased neutrophil infiltration into the rat DRG.
- Neutrophils were found in both the neuronal cell body regions and neurite-rich areas of the DRG.
Conclusions:
- Acute systemic inflammation promotes neutrophil migration into the dorsal root ganglia.
- Neutrophils infiltrate both neuronal and axonal compartments of the DRG in response to systemic inflammation.
