Related Experiment Video
Updated: Apr 9, 2026

Author Spotlight: Investigating Hepatic Adaptations and Prediabetic Progression in Liver Diseases
Published on: October 6, 2023
Interaction Patterns Among Risk Factors for Liver Cancer in Patients With Type 2 Diabetes in Primary Care: A
Sarah Tsz Yui Yau1, Eman Yee Man Leung1, Chi Tim Hung1
1JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong China.
Background And Aims:
Liver cancer is concurrently influenced by a number of risk factors, such as chronic viral hepatitis, heavy alcohol use, and metabolic associated conditions. This study aims to examine whether there are interaction patterns among factors associated with liver cancer risk among patients with diabetes.
Methods:
In this retrospective cohort study, patients who received care for type 2 diabetes in general outpatient clinics between 2010 and 2019 were identified using electronic health records of Hong Kong. Patients were followed up until a cancer diagnosis, death, or December 31st, 2019. The interaction patterns among factors associated with liver cancer risk were examined using conditional inference survival tree.
Results:
A total of 1,995 and 1,969 patients with and without liver cancer were included. Chronic viral hepatitis status appeared as most dominant factor in differentiating the risk of liver cancer. In the absence of chronic viral hepatitis, low lipids and elevated ALT were identified as key risk factor in older females (> 63years) and males respectively. Differential thresholds across different age groups in males were found, with a higher threshold for the younger group (39 U/L for ≤ 53years vs 31 U/L for > 53years).
Conclusion:
Chronic viral hepatitis, sex, age, ALT, and lipids appear to exhibit interaction patterns on liver cancer incidence among patients with diabetes, providing potential targets for public health prevention strategies.
More Related Videos
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Coronary Artery Disease I: Introduction
Psychoneuroimmunology: Diabetes and Cancer
Diabetes: Symptoms, Diagnosis, and Complications
Chronic Pancreatitis II: Collaborative Care
Assessment: