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Updated: Apr 10, 2026
06:15
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
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Updates in Skin Adnexal Tumors
Paul W Harms1, May P Chan1, Thomas Brenn1
1Department of Pathology, University of Michigan, 2800 Plymouth Road, Building 35, Ann Arbor, MI 48109, USA; Department of Dermatology, University of Michigan, 1500 E. Medical Ctr Drive, Ann Arbor, MI 48109, USA.
Dermatologic Clinics
|April 8, 2026
Summary
Accurate classification of cutaneous adnexal tumors is critical for patient outcomes. Recent advances in understanding adnexal carcinomas and their molecular drivers aid diagnosis.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Cutaneous adnexal tumors originate from hair follicles, sweat glands, or sebaceous glands.
- These tumors exhibit a spectrum from benign to malignant and can indicate inherited tumor syndromes.
- Accurate classification is challenging due to existing knowledge gaps.
Purpose of the Study:
- To review recently identified adnexal carcinomas.
- To summarize novel molecular drivers in established adnexal tumor entities.
- To provide diagnostic clues for adnexal tumors.
Main Methods:
- Literature review of recent adnexal tumor research.
- Analysis of morphologic features.
- Evaluation of immunohistochemical and molecular findings.
Main Results:
- Several new adnexal carcinomas have been described.
- New molecular drivers have been identified for various adnexal tumors.
- Morphologic, immunohistochemical, and molecular data offer diagnostic insights.
Conclusions:
- Recent advances have significantly improved the understanding and diagnosis of cutaneous adnexal tumors.
- Identifying molecular drivers is crucial for classifying and managing these tumors.
- Integrated diagnostic approaches incorporating morphology, immunohistochemistry, and molecular data are essential.
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