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Meeting Report: Fourth Correlates of Protection for Next Generation Influenza Vaccines
Alina Tscherne1, Rebecca Jane Cox2,3, Florian Krammer1,4,5,6,7
1Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria.
Influenza and Other Respiratory Viruses
|April 9, 2026
Summary
Next-generation influenza vaccines face challenges with established immune markers like hemagglutination inhibiting (HI) antibodies. Continued collaboration is vital to validate new correlates of protection for evolving vaccine platforms and regulatory needs.
Area of Science:
- Immunology
- Vaccinology
- Public Health
Background:
- Summarizes the fourth "Correlates of Protection for Next Generation Influenza Vaccines" meeting.
- Held in Vienna, Austria, October 15-17, 2025.
Purpose of the Study:
- Discuss challenges in identifying correlates of protection for novel influenza vaccine platforms.
- Address evolving regulatory expectations for vaccine evaluation.
Main Methods:
- Review of discussions and conclusions from an expert meeting.
- Focus on immune markers and their generalizability.
Main Results:
- Established markers like hemagglutination inhibiting (HI) antibodies show limitations across platforms, populations, and age groups.
- Uncertainty persists regarding the generalizability of current immune markers.
Conclusions:
- Strong biological and clinical justification is needed to link immune markers to protection.
- Collaboration among academia, industry, and regulatory agencies is crucial for advancing correlates of protection.
- Efforts align with the 2025 influenza research and development road map.
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