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Updated: Apr 11, 2026

Generation and Labeling of Murine Bone Marrow-derived Dendritic Cells with Qdot Nanocrystals for Tracking Studies
Published on: June 2, 2011
Restoring dendritic cell migration: a gut reaction to boost vaccine efficacy in aging
Liwei Zhao1,2,3, Oliver Kepp1,2,3, Guido Kroemer1,2,3,4
1Institut Gustave Roussy, Université Paris-Saclay, INSERM US23 / CNRS UAR 3655, Metabolomics and Cell Biology Platforms, UMS AMMICa, Villejuif, France.
Abstract:
Aging impairs vaccine responses. Dai et al. reported that defective cDC2 migration in immunized old mice, diminishing humoral and cellular immunity. Oral yeast-derived nanoparticles restore DC migration and vaccine efficacy. These findings establish impaired DC migration as a key mechanism of age-related immune decline, introducing a noninvasive strategy to correct immunosenescence.
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