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Acupoint glucocorticoid injection combined with focused ultrasound for granulomatous lobular mastitis: a
Haixing Wang1, Wenjie Ning1, Hongyan Wang2
1Department of HIFU Treatment Room, The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.
Background:
Granulomatous lobular mastitis (GLM) is a chronic benign inflammatory breast disease with significant treatment challenges. Traditional therapies often result in high recurrence rates and cosmetic concerns.
Objective:
To evaluate the efficacy and safety of combining acupoint glucocorticoid injection with focused ultrasound therapy for GLM treatment.
Methods:
This retrospective study analyzed 186 patients with histologically confirmed GLM treated between July 2021 and December 2024. Patients were divided into three groups: acupoint injection plus focused ultrasound (AI + FUS, n = 64), conventional intralesional steroid injection (CIS, n = 61), and oral corticosteroids (OCS, n = 61). Primary outcomes included complete response rate, recurrence rate, and time to remission. Secondary outcomes assessed cosmetic results and adverse events.
Results:
The AI + FUS group demonstrated significantly higher complete response rates (92.2%) compared to CIS (75.4%) and OCS (68.9%) groups (p < 0.001). Median time to remission was 8.5 weeks (AI + FUS), 12.3 weeks (CIS), and 14.7 weeks (OCS). Recurrence rates at 12 months were 7.8% (AI + FUS), 19.7% (CIS), and 24.6% (OCS). The AI + FUS group showed superior cosmetic outcomes with 87.5% achieving excellent/good results vs. 65.6% (CIS) and 52.5% (OCS). Systemic adverse events were significantly lower in the AI + FUS group (4.7%) compared to OCS (31.1%).
Conclusion:
Combined acupoint glucocorticoid injection with focused ultrasound may represent a useful therapeutic option for GLM, with potential benefits in efficacy, recurrence, cosmetic outcomes, and systemic side effects compared to conventional treatments.
