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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: May 18, 2026

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
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Immune cells and ischemic stroke: A bidirectional Mendelian randomization analysis.

Ni Wang1,2, Wei Guo2, Yan Xie2

  • 1The Second Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.

Medicine
|April 10, 2026
PubMed
Summary

Ischemic stroke (IS) risk may be influenced by immune cell activation, with specific pathways like CD86 and B-cell activating factor receptor showing causal links. This research highlights potential immune modulation strategies for stroke prevention.

Keywords:
BAFF-RCD86Mendelian randomizationcausal relationshipimmune cell signaturesischemic stroke

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Area of Science:

  • Immunology
  • Neurology
  • Genetics

Background:

  • Ischemic stroke (IS) is a major global health concern.
  • Immune cell characteristics are increasingly recognized for their role in IS pathogenesis.

Purpose of the Study:

  • To investigate the causal relationship between 731 immune cell signatures and IS.
  • To elucidate potential immunological mechanisms underlying IS.

Main Methods:

  • A two-sample Mendelian randomization analysis was performed.
  • Genome-wide association study summary statistics for IS and immune traits were utilized.
  • Stringent criteria for instrumental variable selection and sensitivity analyses were applied.

Main Results:

  • Ischemic stroke (IS) may causally influence immune cell activation, increasing CD86+ plasmacytoid dendritic cells and B-cell activating factor receptor expression.
  • Six immunophenotypes were associated with reduced IS risk, including specific monocyte counts and regulatory T-cell expression.
  • Sensitivity analyses confirmed robust associations without evidence of horizontal pleiotropy.

Conclusions:

  • Specific immune cell characteristics causally influence the pathogenesis of IS.
  • Immune modulation via CD86 and B-cell activating factor receptor pathways may impact IS risk.
  • Findings suggest potential for targeted immunotherapeutic strategies in stroke prevention.