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Identification of the Novel HLA-A*30:238 Allele by Next-Generation Sequencing
Jianing Yuan1, Bin Xi1, Zechang Shi1
1Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
HLA
|April 10, 2026
Summary
A novel Human Leukocyte Antigen (HLA) allele, HLA-A*30:238, has been identified. This new allele differs from HLA-A*30:01:01:01 by a single nucleotide substitution.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- Human Leukocyte Antigen (HLA) genes are crucial for immune response.
- Allelic variations within HLA genes can impact immune system function and disease susceptibility.
Purpose of the Study:
- To characterize a newly identified HLA-A allele, designated HLA-A*30:238.
- To describe the specific genetic variation distinguishing HLA-A*30:238 from a known reference allele.
Main Methods:
- Nucleotide sequencing of the HLA-A gene.
- Comparison of the obtained sequence with existing HLA allele databases.
Main Results:
- The novel allele HLA-A*30:238 was identified.
- A single nonsynonymous nucleotide substitution (G>T at position 335) was detected when comparing HLA-A*30:238 to the HLA-A*30:01:01:01 allele.
Conclusions:
- The identification of HLA-A*30:238 expands the known repertoire of HLA-A alleles.
- This specific nucleotide substitution represents a unique genetic marker for this new allele.
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