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Common, Intermediate and Well-Documented HLA Alleles in the Chinese Population: CIWD Version 2025
Yanmin He1, Jianping Cai2,3, Jianping Li4
1HLA Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.
HLA
|May 19, 2026
Summary
The updated China Common and Well-Documented (CWD) HLA allele catalogue now includes 1144 alleles, expanding on the 2018 version. This new catalogue reflects unique HLA genetic diversity in the Chinese population.
Area of Science:
- Immunogenetics
- Population Genetics
- Hematopoietic Stem Cell Transplantation
Background:
- The accurate identification of Human Leukocyte Antigen (HLA) alleles is crucial for hematopoietic stem cell transplantation (HSCT) and understanding population genetics.
- Previous catalogues, such as the China CWD 2018, provided a foundation but required updates to reflect growing donor databases and evolving classification criteria.
Purpose of the Study:
- To update the Chinese catalogue of common and well-documented (CWD) HLA alleles.
- To establish the Chinese Common, Intermediate, and Well-Documented (CIWD) 2025 catalogue based on new criteria (CIWD 3.0.0).
- To analyze the changes and additions compared to the previous China CWD 2018 catalogue.
Main Methods:
- Utilized a database of over 2 million unrelated volunteer donors from the China Marrow Donor Program (CMDP).
- Applied new criteria (CIWD 3.0.0) to classify HLA alleles at the HLA-A, -B, -C, -DRB1, and -DQB1 loci.
- Compared the newly generated China CWD 2025 catalogue with the previous China CWD 2018 catalogue and the CIWD 3.0.0 catalogue.
Main Results:
- The China CWD 2025 catalogue designates 1144 CWD alleles, a significant increase from the 676 alleles in the 2018 version.
- Specific allele classifications, including HLA-B*15:58, HLA-C*17:01, HLA-DRB1*08:01, and HLA-DRB1*11:06, differ from the previous catalogue.
- The 2025 catalogue includes all previously well-documented alleles except for HLA-B*15:58 and HLA-DRB1*08:01.
- Identified 195 common, 25 intermediate, and 167 well-documented alleles consistent with the CIWD 3.0.0 catalogue.
Conclusions:
- The China CIWD 2025 catalogue represents a substantial update and expansion of HLA allele information for the Chinese population.
- This catalogue effectively captures the unique HLA genetic diversity within China.
- It serves as a valuable supplement to the international CIWD 3.0.0 catalogue, aiding in donor selection and population genetic studies.
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