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Alejo Corrales¹, Andrea Abadi², Gastón Bartoli³

¹Magíster en Biología Molecular e Ingeniería Genética, Universidad Favaloro. Docente de la Universidad Nacional de Tucumán (UNT). Presidente del Capítulo de Psiquiatría Genética, Asociación Argentina de Psiquiatras (AAP), Buenos Aires, Argentina.. alejocorrales@hotmail.com.

Vertex (Buenos Aires, Argentina)

|April 11, 2026

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Summary

This summary is machine-generated.

This consensus synthesizes current evidence on adult schizophrenia treatment, covering pharmacological and psychosocial strategies. It provides updated recommendations for comprehensive, person-centered care, including managing acute exacerbations and long-term maintenance.

Area of Science:

Psychiatry
Clinical Pharmacology
Evidence-Based Medicine

Background:

Schizophrenia requires ongoing, evidence-based therapeutic management.
Previous consensus parts established the methodological framework.
Adult schizophrenia treatment necessitates updated, comprehensive strategies.

Purpose of the Study:

To synthesize current scientific evidence on therapeutic approaches for adult schizophrenia.
To provide updated recommendations for the comprehensive management of schizophrenia in adults.
To guide clinicians in optimizing treatment strategies for schizophrenia.

Main Methods:

Multidisciplinary expert panel review.
Exhaustive and systematic literature review.

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Structured discussion and consensus-building process.

Main Results:

Recommendations cover pre-prescription considerations, acute exacerbation management, and first/second-line pharmacotherapy.
Detailed analysis of clozapine, long-acting injectables (LAI), antipsychotic switching, augmentation, and combination therapies.
Evidence on complementary therapies (ECT, rTMS), adherence, response/remission/recovery, relapse prevention, maintenance, comorbidities, pseudoresistance, and psychosocial interventions.

Conclusions:

An integral, longitudinal, and person-centered approach is essential for schizophrenia management.
Updated evidence supports diverse pharmacological and psychosocial interventions.
The consensus provides a framework for optimizing adult schizophrenia care.