Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of the Vascular System01:20

Overview of the Vascular System

3.8K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.8K
Vascular Resistance01:20

Vascular Resistance

14.1K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
14.1K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

4.0K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
4.0K
Vascular Spasm01:16

Vascular Spasm

5.0K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
5.0K
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

1.5K
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antioxidant Probucol Reduces Mortality in Mice Exposed to Lethal Doses of Ionizing Radiation.

Radiation research·2026
Same author

Association between social isolation and increased arterial stiffness in older adults: a cross-sectional study.

Scientific reports·2026
Same author

Renal Artery Stenosis Detected Early Through Routine Health Checkups.

JACC. Case reports·2026
Same author

A cut-off value for endothelial dysfunction based on the triglyceride-glucose index.

Scientific reports·2026
Same author

Low-Intensity Pulsed Ultrasound Therapy for Patients With Rutherford Stage 4 Peripheral Arterial Disease.

JACC. Case reports·2026
Same author

IgA Vasculitis Developing during Trastuzumab Emtansine Therapy for HER2-positive Breast Cancer.

Internal medicine (Tokyo, Japan)·2026
Same journal

The Dawn of the Era of Clopidogrel Monotherapy Following Coronary Artery Disease.

JACC. Asia·2026
Same journal

Beyond Valve Area: Understanding Exercise Intolerance in Severe Rheumatic Mitral Stenosis.

JACC. Asia·2026
Same journal

Effect of Colchicine on Left Atrial Mechanics in Rheumatic Heart Disease: The COL-RHD A Pilot Trial.

JACC. Asia·2026
Same journal

Health Status in Heart Failure With Preserved Ejection Fraction in Asia: Insights From Global Trials.

JACC. Asia·2026
Same journal

Post-TAVR Conduction Disturbances: Risk Stratification Using Consensus Algorithm and Membranous Septum Length.

JACC. Asia·2026
Same journal

Serum Atherogenic Index and Cardiovascular Risk in Young Adults: From Early Detection to Preventive Action.

JACC. Asia·2026
See all related articles

Related Experiment Video

Updated: Apr 13, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

28.2K

Association Between Complete Right Bundle Branch Block and Vascular Endothelial Function.

Aya Mizobuchi1, Tatsuya Maruhashi1, Yusuke Saito1

  • 1Department of Regeneration and Medicine, Division of Radiation Medical Science Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.

JACC. Asia
|April 11, 2026
PubMed
Summary
This summary is machine-generated.

Complete right bundle branch block (CRBBB) is linked to endothelial dysfunction, indicating it’s not always a benign finding. This suggests CRBBB may signal underlying vascular issues, impacting cardiovascular risk assessment.

Keywords:
complete right bundle branch blockflow-mediated vasodilationnitroglycerine-induced vasodilationvascular function

More Related Videos

Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

16.8K
Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

44.7K

Related Experiment Videos

Last Updated: Apr 13, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

28.2K
Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

16.8K
Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

44.7K

Area of Science:

  • Cardiology
  • Vascular Biology
  • Electrocardiography

Background:

  • Complete right bundle branch block (CRBBB) is a common ECG finding, often considered benign.
  • Emerging evidence links CRBBB to arteriosclerosis and increased cardiovascular risk.

Purpose of the Study:

  • To investigate the association between CRBBB and vascular function.
  • To evaluate endothelial and vascular smooth muscle function in individuals with and without CRBBB.

Main Methods:

  • Included 1,308 individuals (55 with CRBBB, 1,253 controls).
  • Assessed endothelial function via flow-mediated vasodilation (FMD).
  • Assessed vascular smooth muscle function via nitroglycerine-induced vasodilation (NID).

Main Results:

  • FMD was significantly lower in the CRBBB group (3.2%) compared to controls (4.6%), P < 0.001.
  • CRBBB was significantly associated with endothelial dysfunction (OR: 1.84; P = 0.047).
  • NID was lower in the CRBBB group (11.5%) vs controls (13.1%), P = 0.024, but no significant association with vascular smooth muscle dysfunction was found (OR: 1.09; P = 0.816).

Conclusions:

  • CRBBB is associated with endothelial dysfunction.
  • These findings suggest CRBBB is not always a benign finding from a vascular function perspective.
  • CRBBB may serve as an indicator for further vascular risk assessment.