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Related Concept Videos

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Related Experiment Video

Updated: Apr 14, 2026

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
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Spontaneous Bone Neo-formation After Mandibular Resection: Case Report and a Scoping Review.

André Luís Costa Cantanhede1, Roque Soares Martins Neto1, Erika Martins Pereira2

  • 1Federal University of Maranhao Hospital, Rua Barão de Itapari, 227, Centro, São Luis, MA 65020-070 Brazil.

Journal of Maxillofacial and Oral Surgery
|April 13, 2026
PubMed
Summary

Pediatric mandibular tumors can be challenging to reconstruct. This study highlights spontaneous bone neo-formation (SBNF) potential in children, offering insights for future reconstructive strategies.

Keywords:
Bone regenerationMandibular reconstructionSurgery

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Area of Science:

  • Pediatric oncology
  • Oral and maxillofacial surgery
  • Regenerative medicine

Background:

  • Mandibular tumors in children are often benign but can be aggressive.
  • Reconstruction of mandibular defects post-tumor ablation presents significant challenges.
  • Pediatric periosteum has high osteogenic potential for new bone formation.

Purpose of the Study:

  • To present an uncommon case of spontaneous bone neo-formation (SBNF) in a pediatric patient.
  • To review existing literature on SBNF following mandibular resection in children.

Main Methods:

  • Case report of a 3-year-old patient with central giant cell granuloma.
  • Partial mandibular resection and subsequent observation for bone regeneration.
  • Literature review of SBNF cases after mandibular resection.

Main Results:

  • Successful well-shaped bone neo-formation of the ramus-condyle unit observed.
  • Literature review outlines representative features of SBNF in similar cases.

Conclusions:

  • The periosteum's role in pediatric bone neo-formation warrants further investigation.
  • SBNF is a promising avenue for mandibular reconstruction in children.