Mussel-inspired NIR-responsive multifunctional electrospun gelatin-based nanofibers for infected severe burn wound...

Severe burn wounds are highly susceptible to bacterial infection due to the loss of the skin barrier, which significantly impedes healing and increases mortality. Developing advanced dressings that combine potent antimicrobial activity with tissue regeneration is therefore of great clinical importance. In this study, a multifunctional nanofibrous dressing (BBR/P@Fe NFs) was constructed by co-loading berberine (BBR) and a polydopamine‑iron coordination complex (P@Fe) into gelatin-based nanofibers via electrospinning. Experimental results indicate that the BBR/P@Fe NFs achieve strong tissue adhesion and rapid hemostasis by employing the polydopamine-mediated mussel-inspired adhesion mechanism, and generate a potent antibacterial effect through the photothermal-chemical synergistic antibacterial strategy. Additionally, BBR/P@Fe NFs can facilitate angiogenesis and reduce inflammation to promote skin regeneration in severely burned wounds with bacterial infections. These findings confirm that the biomimetic BBR/P@Fe NFs constitute a promising multifunctional platform that can address the clinical challenges of treating severely infected burns.