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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Light-responsive DNA nanostructures.

Bharath Raj Madhanagopal^1,2, Ting Wang², Arun Richard Chandrasekaran^3,4

¹Department of Nanoscale Science and Engineering, University at Albany, State University of New York, Albany, NY, USA.

Nature Reviews. Chemistry

|April 13, 2026

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This summary is machine-generated.

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Light-responsive DNA nanostructures offer dynamic control for advanced applications. This review explores light-responsive functional groups, design strategies, and uses in diagnostics and drug delivery.

Area of Science:

Biotechnology
Materials Science
Nanotechnology

Background:

DNA nanostructures possess inherent properties like biocompatibility and programmability.
External stimuli, particularly light, can reconfigure DNA nanostructures.
Light responsiveness enhances DNA nanostructures' functional capabilities.

Purpose of the Study:

To review emerging research trends in light-responsive DNA nanostructures.
To focus on available light-responsive functional groups and their incorporation into DNA.
To discuss strategies for designing and constructing these nanostructures and their applications.

Main Methods:

Incorporation of light-responsive linkers into DNA strands.
Chemical synthesis of various light-responsive moieties.

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Last Updated: Apr 15, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

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Published on: September 27, 2019

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

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Design and Synthesis of a Reconfigurable DNA Accordion Rack

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Published on: August 15, 2018

Design and construction of DNA nanostructures with controlled reconfiguration.

Main Results:

Light-responsive DNA nanostructures exhibit controlled reconfiguration.
These structures show high thermal stability and enhanced nuclease resistance.
Triggered detachment of guest molecules from nanostructures is achievable.

Conclusions:

Light-responsive DNA nanostructures are versatile tools for various applications.
Emerging research focuses on novel functional groups and design strategies.
Applications span diagnostics, drug delivery, data storage, and more.