Search research articles

Search research articles

Related Experiment Video

Updated: May 19, 2026

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

Published on: February 9, 2024

Aptamer-based DNA nanoswitches for multiplexed protein detection.

Sravya Kovvali¹, Camryn A Beckles^1,2, Arun Richard Chandrasekaran^1,3

¹The RNA Institute, University at Albany, State University of New York, Albany, NY, 12222 USA.

Biorxiv : the Preprint Server for Biology

|May 18, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inosine incorporation in DNA nanostructures and 3D DNA crystals.

bioRxiv : the preprint server for biology·2026

Same author

Ligation-assisted target recycling for DNA nanoswitch biosensors.

bioRxiv : the preprint server for biology·2026

Same author

Paranemic Cohesion of DNA under Isothermal Conditions.

JACS Au·2026

Same author

Light-responsive DNA nanostructures.

Nature reviews. Chemistry·2026

Same author

DNA Nanostructures for siRNA Delivery.

Bioconjugate chemistry·2026

Same author

Left-Handed Helices in DNA Nanotechnology.

JACS Au·2026

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Researchers developed a new method for detecting proteins using aptamers and DNA nanoswitches. This simple, sensitive, and specific platform shows promise for clinical diagnostics and biomedical research.

Area of Science:

Biotechnology
Molecular Biology
Nanotechnology

Background:

Protein detection is crucial for clinical diagnostics, healthcare, and research.
Existing methods can be complex or lack sensitivity and specificity.
Modular platforms offer a versatile approach to biosensing.

Purpose of the Study:

To develop a simple, modular platform for sensitive and specific protein detection.
To combine aptamer-based recognition with DNA nanoswitch technology.
To demonstrate the platform's capability for dual protein detection.

Main Methods:

Utilized aptamer-based recognition for targeting specific proteins.
Employed conformationally-responsive DNA nanoswitches for signal transduction.

More Related Videos

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics

Published on: December 8, 2023

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

Related Experiment Videos

Last Updated: May 19, 2026

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

Published on: February 9, 2024

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics

Published on: December 8, 2023

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

Integrated aptamers and nanoswitches into a modular detection system.

Performed dual detection of thrombin and Vascular Endothelial Growth Factor (VEGF).

Main Results:

Achieved simple, sensitive, and specific detection of target proteins.
Demonstrated successful dual detection of thrombin and VEGF.
The DNA nanoswitch platform showed high responsiveness to protein binding.

Conclusions:

The developed aptamer-DNA nanoswitch platform offers a promising tool for protein detection.
This modular approach facilitates sensitive and specific analysis of clinically relevant proteins.
The system has potential applications in diagnostics, healthcare, and biomedical research.