Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Helicases00:55

DNA Helicases

24.9K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
24.9K
The DNA Helix01:16

The DNA Helix

161.7K
Overview
161.7K
The DNA Helix01:07

The DNA Helix

31.6K
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
31.6K
The DNA Helix01:16

The DNA Helix

62.8K
62.8K
Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

17.2K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
17.2K
DNA as a Genetic Template02:05

DNA as a Genetic Template

28.7K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
28.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inosine incorporation in DNA nanostructures and 3D DNA crystals.

bioRxiv : the preprint server for biology·2026
Same author

Aptamer-based DNA nanoswitches for multiplexed protein detection.

bioRxiv : the preprint server for biology·2026
Same author

Paranemic Cohesion of DNA under Isothermal Conditions.

JACS Au·2026
Same author

Light-responsive DNA nanostructures.

Nature reviews. Chemistry·2026
Same author

DNA Nanostructures for siRNA Delivery.

Bioconjugate chemistry·2026
Same author

Mechanistic insights into crossover-dependent nuclease resistance of PX <i>vs.</i> dsDNA using enhanced sampling.

Nanoscale·2026
Same journal

DeepDOX1: A Dual-Drive Framework Integrating Deep Learning and First-Principles Quantum Chemistry for Drug-Protein Affinity Prediction.

JACS Au·2026
Same journal

Catalyst-Controlled Regiodivergent C-H Olefination of Furanyl Carbamates through a Rational Approach.

JACS Au·2026
Same journal

Charting the Biosynthetic Landscape of Hybrid Polyketide-Nonribosomal Peptide-Specialized Lipids.

JACS Au·2026
Same journal

Valence-State-Dependent Surface Lattice Oxygen in CeO<sub>2</sub>‑Modified VPO Catalysts: Elucidating the Mechanism of <i>n</i>‑Butane Selective Oxidation to Maleic Anhydride.

JACS Au·2026
Same journal

Quantitative Insights into Pressure-Dependent Mass Transport and Reaction Kinetics in Electrochemical CO<sub>2</sub> Reduction.

JACS Au·2026
Same journal

3‑Methylthiopropionic Acid Kills Carbapenem-Resistant <i>Klebsiella pneumoniae</i> by Disrupting Membrane Integrity and Bioenergetics.

JACS Au·2026
See all related articles

Related Experiment Video

Updated: Mar 28, 2026

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
08:00

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

7.3K

Left-Handed Helices in DNA Nanotechnology.

Sangeetha Selvam1, Johnsi Mathivanan2, Arun Richard Chandrasekaran1,2

  • 1The RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States.

JACS Au
|March 27, 2026
PubMed
Summary
This summary is machine-generated.

DNA nanotechnology utilizes DNA for nanoscale construction, exploring left-handed helices like Z-DNA and L-DNA alongside B-DNA. This review covers their applications and future potential in nanostructure design.

Keywords:
DNA double helixDNA nanotechnologyDNA origamiDNA topologyL-DNAZ-DNAleft-handed DNA

More Related Videos

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

7.2K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.6K

Related Experiment Videos

Last Updated: Mar 28, 2026

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
08:00

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

7.3K
Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

7.2K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.6K

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Molecular Biology

Background:

  • DNA nanotechnology commonly employs right-handed B-form DNA for creating nanoscale structures.
  • Alternative nucleic acid structures, including left-handed helices, offer novel design possibilities.

Purpose of the Study:

  • This perspective reviews the use of left-handed helices in DNA nanotechnology.
  • It explores their applications and discusses their future impact on nanostructure design and assembly.

Main Methods:

  • Discussion of Z-DNA, a known left-handed DNA structure.
  • Analysis of L-DNA strands forming left-handed duplexes.
  • Examination of structures with global left-handed helicity built on right-handed B-DNA units.

Main Results:

  • Left-handed helices, including Z-DNA and L-DNA, are viable alternatives to B-DNA in nanostructure construction.
  • Novel nanostructures can be designed utilizing these left-handed helical forms.
  • These structures offer unique properties for advanced nanotechnology applications.

Conclusions:

  • Left-handed helices represent an expanding area within DNA nanotechnology.
  • Their strategic use enables the creation of diverse and complex nanostructures.
  • Further research into left-handed helices promises significant advancements in the field.