Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.9K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.9K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

1.2K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.2K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

964
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
964
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

523
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
523
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

466
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
466
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

14.1K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
14.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Compact and bench-top common-path interferometric biosensor utilizing guided mode resonance phase enhancement.

Optics letters·2025
Same author

Assessment of Determinants and Causes of Preterm Births Among Postnatal Mothers: A Retrospective Study.

Cureus·2025
Same author

The Psychological Impact of Male Infertility: A Narrative Review.

Cureus·2025
Same author

The Impact of Climate Change and Environmental Stressors on Maternal Mental Health: A Narrative Review.

Cureus·2025
Same author

Hybrid MoSe<sub>2</sub>/P3HT Transistor for Real-Time Ammonia Sensing in Biofluids.

ACS applied materials & interfaces·2024
Same author

Prevalence and risk factor of anemia among pregnant women admitted in antenatal ward in PBMH Bhubaneswar, Odisha.

Journal of family medicine and primary care·2024
Same journal

A Retrospective Analysis of Cardiac Anatomy in Patients Undergoing the Fontan Operation.

Cureus·2026
Same journal

A Narrative Review of the Potential Impact of Next-Generation Tobacco and Nicotine Products on Cardiovascular Health.

Cureus·2026
Same journal

A Prospective Comparative Study for the Evaluation of Digital Learning as an Academic Tool for MBBS Phase III Students.

Cureus·2026
Same journal

Crossing the Septum: May-Thurner Syndrome and Patent Foramen Ovale as a Dual Mechanism for Recurrent Ischemic Stroke.

Cureus·2026
Same journal

Physical Restraint Practices, Attitudes, and Ethical Perceptions Among Intensive Care Unit (ICU) Doctors and Nurses in Morocco: A Cross-Sectional Survey Highlighting the Training-Use Paradox.

Cureus·2026
Same journal

Reversible Rapidly Progressive Dementia Due to Cerebral Amyloid Angiopathy.

Cureus·2026
See all related articles

Related Experiment Video

Updated: Apr 15, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

1.4K

The Interplay Between Rheumatoid Arthritis and Pregnancy Outcomes: A Narrative Review.

Nilam Mishra1, Karishma Bal1, Bishnupriya Lenka2

  • 1Obstetrics and Gynaecology, Kalinga Institute of Nursing Sciences (KINS), Bhubaneswar, IND.

Cureus
|April 14, 2026
PubMed
Summary
This summary is machine-generated.

Rheumatoid arthritis (RA) management during pregnancy requires careful planning. While RA symptoms may improve during pregnancy, risks to mother and baby persist, necessitating preconception counseling and safe medication choices.

Keywords:
autoimmune diseasedisease-modifying therapiesfetal healthimmunological changesmaternal healthpreconception counsellingpregnancy complicationspregnancy outcomesra medicationsrheumatoid arthritis

More Related Videos

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

3.5K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.5K

Related Experiment Videos

Last Updated: Apr 15, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

1.4K
Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

3.5K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.5K

Area of Science:

  • Rheumatology
  • Immunology
  • Obstetrics

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune condition often affecting women of reproductive age.
  • Pregnancy planning and management in RA patients are increasingly important due to evolving therapies.

Purpose of the Study:

  • To review pathophysiological changes of RA during pregnancy.
  • To evaluate maternal and fetal outcomes in RA patients.
  • To examine the safety of RA medications and emphasize preconception care.

Main Methods:

  • Narrative review of studies published between 2015 and 2025.
  • Inclusion of cohort studies, population registries, and clinical research.
  • Analysis of immunological, hormonal, obstetric, and neonatal data.

Main Results:

  • Pregnancy-induced immune/hormonal shifts often reduce RA symptoms mid-pregnancy but flares post-delivery are common.
  • Women with RA face higher risks of miscarriage, preeclampsia, gestational diabetes, and C-sections.
  • Infants of mothers with RA have increased risks of preterm birth, low birth weight, and SGA.
  • Methotrexate is contraindicated; hydroxychloroquine and TNF inhibitors are relatively safe.

Conclusions:

  • Favorable pregnancy outcomes are achievable with preconception planning, disease control, and multidisciplinary care for RA patients.
  • Personalized treatment strategies and ongoing research are vital for improving reproductive health in women with RA.