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    Area of Science:

    • Epidemiology
    • Infectious Diseases
    • Vaccinology

    Background:

    • Tetanus is a serious, vaccine-preventable disease caused by Clostridium tetani toxin.
    • Despite immunization, tetanus cases persist, particularly in unvaccinated individuals.

    Purpose of the Study:

    • To analyze national surveillance data for tetanus cases in the United States from 2009-2023.
    • To identify trends in incidence, demographics, vaccination status, and outcomes.

    Main Methods:

    • Utilized the National Notifiable Diseases Surveillance System (NNDSS) for case identification.
    • Collected data on vaccination history, wound details, medical care, and clinical course.
    • Analyzed reported cases from 47 states and the District of Columbia.

    Main Results:

    • Reported 402 tetanus cases and 37 deaths between 2009-2023.
    • Males had higher incidence overall, but women aged ≥80 years had the highest incidence (0.27 per million).
    • 43.9% of individuals with known vaccination history were unvaccinated; case-fatality rate was 12.4%, highest in older adults.

    Conclusions:

    • Tetanus continues to occur in the US despite being preventable.
    • Significant vaccination gaps exist, contributing to ongoing cases and deaths.
    • Enhanced vaccination strategies and wound care are crucial for tetanus prevention.