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Role of Pelvic Lymph Node Dissection for Clinically Localized Prostate Cancer: Should It be Done?
Yuval Elkun1, Raghav Gupta1, Murilo De Almeida Luz1
1Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
The Urologic Clinics of North America
|April 15, 2026
Summary
Pelvic lymph node dissection (PLND) during prostate cancer surgery offers accurate staging but its therapeutic benefits remain unclear. Further research may reveal its role in novel immunotherapy strategies.
Area of Science:
- Urology
- Oncology
- Surgical Oncology
Background:
- The role of pelvic lymph node dissection (PLND) during radical prostatectomy for localized prostate cancer is debated.
- PLND provides accurate cancer staging but its therapeutic advantages are inconclusive.
Purpose of the Study:
- To review PLND templates and supporting/opposing data.
- To explore future patient selection criteria for PLND.
- To theorize the role of pelvic lymph nodes in immunotherapy.
Main Methods:
- Literature review of PLND templates.
- Analysis of data supporting and refuting PLND.
- Exploration of future research directions.
Main Results:
- Data on the therapeutic benefits of PLND is inconclusive.
- Various PLND templates exist.
- Pelvic lymph nodes may be crucial for immunotherapy development.
Conclusions:
- The therapeutic value of PLND in prostate cancer remains controversial.
- Refined patient selection for PLND is needed.
- Pelvic lymph nodes present a potential target for future immunotherapies.
