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Protocolized vs. Conventional Sedation Among Mechanically Ventilated Children in a Pediatric Intensive Care Unit - A

Pradeep Babu Uppaluri1, Suresh Kumar Angurana2

  • 1Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.

Indian Journal of Pediatrics
|April 15, 2026
PubMed
Summary

No abstract available in PubMed .

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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

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