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[Electron microscopic study of experimental infection. 1. A study of the dynamics of staphylococcal infection]

V I Korinteli, A N Meĭpariani, T G Chanishvili

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |February 1, 1979
    PubMed

    Insights

    Antibiotic-resistant Staphylococcus bacteria invade chick embryo fibroblast cells. These bacteria cause cell damage, leading to vacuolization and eventual destruction of the host cells.

    Area of Science:

    • Microbiology
    • Cell Biology
    • Infectious Diseases

    Context:

    • Investigating Staphylococcus aureus pathogenesis.
    • Utilizing chick embryo fibroblasts as a model system.
    • Employing electron microscopy for ultrastructural analysis.

    Purpose:

    • To elucidate the cellular mechanisms of Staphylococcus infection.
    • To observe the interaction between antibiotic-resistant Staphylococcus and host cells.
    • To characterize the cytopathic effects induced by Staphylococcus strain 79.

    Summary:

    • Electron microscopy revealed antibiotic-resistant Staphylococcus (strain 79) invading chick embryo fibroblast cytoplasm.
    • Observed progressive vacuolization within infected fibroblasts.
    • Demonstrated complete cellular destruction as a consequence of Staphylococcus invasion.

    Impact:

    • Provides insights into the virulence factors of antibiotic-resistant Staphylococcus.
    • Highlights the susceptibility of fibroblasts to bacterial invasion.
    • Informs potential therapeutic strategies against staphylococcal infections.

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