Periocular Rejuvenation with PRF Gel.

Area of Science:

• Aesthetic Medicine
• Regenerative Medicine
• Dermatology

Background:

• Age-related periorbital volume loss causes tear troughs and infraorbital hollowing, leading to a fatigued appearance.
• Platelet concentrates have a history of use for their regenerative properties.
• Platelet-Rich Fibrin (PRF) Gel is a novel, autologous alternative to hyaluronic acid (HA) fillers for periorbital rejuvenation.

Purpose of the Study:

• To introduce Platelet-Rich Fibrin (PRF) Gel as a conservative and natural option for periorbital rejuvenation.
• To describe the preparation and application of PRF Gel for addressing under-eye hollowness.

Main Methods:

• PRF Gel is prepared by combining denatured albumin and liquid PRF.
• Specific centrifugation speeds and times are used for each component (albumin: 2600 rpm, 7 min; liquid PRF: 1100 rpm, 5 min).
• The components are mixed in a 3.5:1.5 cc ratio to create an injectable gel.

Main Results:

• PRF Gel is suitable for patients desiring a conservative approach, including those with prior HA complications or lymphatic issues.
• Treatment involves minimal downtime and fewer post-operative restrictions compared to HA fillers.
• Prospective observations indicate progressive volume improvement with repeated PRF Gel treatments.

Conclusions:

• PRF Gel presents a new, autologous treatment for under-eye rejuvenation.
• It provides a conservative and natural alternative for patients seeking to address tear troughs and infraorbital hollowing.
• Further refinement of PRF Gel preparation protocols may enhance clinical outcomes.