Systemic immune-inflammatory index predicts all-cause and cardiovascular mortality in metabolic syndrome: A
Yao Sun1, Shuguang Yang2, Zengli Xiao2
1Department of Critical Care Medicine, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing, PR China; Department of Critical Care Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, PR China.
Background:
This study aims to evaluate the association between SII and the prevalence of MetS in the female population of the United States, utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2013-2018.
Methods:
The study analyzed data from 6140 participants. The association between SII and MetS was investigated using both univariate and multivariable analyses. Additionally, the relationship between SII and all-cause as well as cardiovascular mortality was assessed through Cox proportional hazards regression models.
Results:
MetS was prevalent in 37.52% of the study population. Participants diagnosed with MetS showed higher SII scores compared to those without MetS. There was a nonlinear "J"-shaped dose-response relationship between increased SII levels and increased all-cause mortality in the MetS population. The same trend of relationship between SII levels and cardiovascular mortality was observed in people aged 60-years and older in the MetS population.
Conclusion:
The results of this study suggest that there is a significant association between elevated SII and the presence of MetS, and that systemic inflammation indicated by SII may contribute to the development and progression of MetS and its associated complications. Further studies are warranted to elucidate the underlying mechanisms between SII and MetS and to evaluate the clinical utility of SII in risk stratification and management strategies.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:21Myocarditis I: Introduction
01:30Coronary Artery Disease I: Introduction
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:12Chronic Inflammation: Introduction