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CDCA-Derived NE3TA Conjugate for Liver-Selective ⁶⁴Cu PET Imaging.

Haixing Wang¹, Siyuan Ren¹, Nilantha Bandara²

¹Department of Chemistry, Illinois Institute of Technology, Chicago, Illinois 60616-3717, United States.

|April 20, 2026

Summary

This summary is machine-generated.

Researchers developed a novel Copper-64 (64Cu)-labeled tracer using a CDCA-derived chelator for liver-selective positron emission tomography (PET) imaging. This tracer shows high stability and excellent liver uptake, paving the way for improved hepatobiliary imaging applications.

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Area of Science:

Nuclear medicine
Radiopharmaceutical chemistry
Medical imaging

Background:

Positron emission tomography (PET) is a sensitive imaging technique for visualizing biological processes.
Assessing liver function with PET is challenging due to the lack of liver-selective tracers.
Copper-64 (64Cu) is a promising radionuclide for PET imaging.

Purpose of the Study:

To develop and evaluate a novel liver-selective PET tracer for hepatobiliary imaging.
To synthesize and characterize a Copper-64 (64Cu)-labeled bifunctional chelator conjugate with CDCA.
To assess the stability, radiolabeling efficiency, and biodistribution of the novel tracer.

Main Methods:

Development of a bifunctional chelator (3p-C-NE3TA) for Copper-64 (64Cu) chelation.
Synthesis of a CDCA-derived chelator conjugate (3p-C-NE3TA-CDCA).
Radiolabeling of the conjugate with 64Cu and evaluation of in vitro and in vivo properties in mice.

Main Results:

Efficient radiolabeling of 3p-C-NE3TA-CDCA with 64Cu achieved at room temperature.
The 64Cu-labeled tracer demonstrated high stability in human serum.
Prominent and selective hepatic uptake with rapid clearance from blood and non-target tissues was observed in mice.

Conclusions:

The 64Cu-labeled 3p-C-NE3TA-CDCA conjugate is a promising candidate for liver-selective PET imaging.
The tracer exhibits excellent radiolabeling efficiency, stability, and biodistribution characteristics.
This development could advance the clinical application of PET for hepatobiliary function assessment.