Stereotactic Gamma Knife radiosurgery: Past, present and future.

Area of Science:

• Neurosurgery
• Radiation Oncology
• Medical Physics

Background:

• Gamma Knife stereotactic radiosurgery (GKSRS) has been a cornerstone in treating brain and body conditions since the late 1950s.
• The technology has continuously evolved, integrating advanced features for precision and efficiency.

Purpose of the Study:

• To review the historical development, current capabilities, and future trajectory of GKSRS.
• To highlight the innovations in the latest GKSRS Esprit system.

Main Methods:

• Review of historical data and technological advancements in GKSRS.
• Discussion of the capabilities of the latest GKSRS Esprit system, including treatment delivery paradigms.
• Analysis of integrated workflows for frame-based and mask-based treatments.

Main Results:

• GKSRS development over the past 30 years is considered a major success.
• The Esprit system offers enhanced technical capabilities and supports diverse treatment fractionation methods.
• GKSRS has significantly influenced stereotactic brain radiosurgery and body radiotherapy.

Conclusions:

• GKSRS has a proven track record of success and continues to be a vital tool in radiation therapy.
• Ongoing advancements are expected to expand its application and patient benefit worldwide.
• The system's versatility supports both single-fraction and hypofractionated treatment protocols.