Association of S100B Serum Level With Postoperative Cognitive Dysfunction (POCD) in Non-Cardiac Surgery: A...

Area of Science:

• Neuroscience
• Biochemistry
• Surgical Research

Background:

• Postoperative cognitive dysfunction (POCD) is a persistent cognitive decline post-surgery.
• S100B, a calcium-binding protein, is found in the brain and its serum levels are investigated for POCD association.
• Non-cardiac surgeries are a focus for understanding POCD development.

Purpose of the Study:

• To systematically review and meta-analyze the association between S100B serum levels and POCD.
• To evaluate the diagnostic potential of S100B in predicting POCD after non-cardiac procedures.

Main Methods:

• Systematic literature search across major databases (PubMed/Medline, Scopus, Web of Science, Google Scholar).
• Inclusion of studies measuring pre- and post-operative S100B serum levels in non-cardiac surgery patients.
• Application of a random effects model for meta-analysis to determine S100B's association with POCD.

Main Results:

• 11 studies were included from 280 screened articles.
• A pooled odds ratio (OR) of 1.77 (95% CI: 1.17-2.67) indicated a significant association between S100B levels and POCD.
• Subgroup analyses revealed higher ORs in patients aged ≥65 years (OR=1.94) and in studies conducted in Europe (OR=1.85).

Conclusions:

• Serum S100B levels are associated with the occurrence of POCD following non-cardiac surgery.
• S100B monitoring shows promise for the early diagnosis of POCD.
• Findings support the development of S100B-based preventive strategies for POCD.