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Large language model-assisted radiology reporting in a single-radiologist implementation: a retrospective cohort
1Department of Radiology, Mayo Clinic, Phoenix, USA. tan.nelly@mayo.edu.
Abdominal Radiology (New York)
|April 20, 2026
Summary
Large language models (LLMs) improved radiologist efficiency for CT scans but not MRI, reducing interpretation times. Further research is needed to optimize LLM integration for complex imaging tasks and enhance adoption.
Area of Science:
- Medical Imaging Informatics
- Artificial Intelligence in Healthcare
- Radiology Workflow Optimization
Background:
- Radiologist burnout is prevalent, impacting approximately 40% of US radiologists.
- Large language models (LLMs) show potential for improving workflow efficiency in radiology.
- Limited real-world data exists on the implementation and impact of LLMs in clinical radiology settings.
Purpose of the Study:
- To evaluate the impact of an LLM-assisted workflow on radiologist efficiency.
- To assess radiologist satisfaction and adoption drivers using the Unified Theory of Acceptance and Use of Technology (UTAUT) framework.
Main Methods:
- Retrospective cohort study at Mayo Clinic Arizona involving a single fellowship-trained abdominal radiologist.
- Comparison of baseline and post-implementation periods using a custom generative pre-trained transformer (based on ChatGPT Enterprise Model 5.2).
- Analysis of inter-study interval time as a proxy for interpretation time, with assessment of UTAUT constructs.
Main Results:
- LLM assistance significantly reduced inter-study intervals for outpatient CT interpretation (10-11.5 min reduction, p<0.01).
- No significant efficiency improvement was observed for MRI interpretation (p>0.05).
- The radiologist reported improved work-life balance for CT but neutral satisfaction for complex MRI templates; training required 10 hours.
Conclusions:
- LLM-assisted workflows can enhance efficiency for standardized CT studies, potentially reducing documentation burden.
- No clear efficiency benefits were observed for MRI in this sample, highlighting the importance of task-technology fit.
- Performance expectancy and task-technology fit are key drivers for LLM adoption in radiology, necessitating alignment with task complexity.

