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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Updated: Apr 23, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

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Published on: March 25, 2019

MicroRNA-Governed Autocatalytic Fenton Nanoplatform for Cancer-Selective Theranostics.

Lu-Yao Wang¹, Wen-Jing Liu¹, Fei Ma¹

¹School of Chemistry and Chemical Engineering, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing 211189, China.

|April 22, 2026

Summary

This summary is machine-generated.

This study introduces a novel nanoplatform for cancer treatment using miRNA-regulated Fenton reactions. This intelligent system enhances tumor selectivity and imaging for effective cancer therapy.

Keywords:

DNAzyme Fenton reaction cancer chemodynamic therapy gene silencing microRNA

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Area of Science:

Biomedical Engineering
Nanotechnology
Cancer Therapy

Background:

Fenton reaction-based chemodynamic therapy (CDT) shows promise for cancer treatment but suffers from low efficiency and poor tumor selectivity.
Current CDT strategies require improvements in tumor-specific control and enhanced Fenton reaction efficiency.

Purpose of the Study:

To develop an intelligent DNAzyme-metal-tannic acid (DzMT) nanoplatform for miRNA-regulated, tumor-selective, imaging-guided chemodynamic therapy.
To overcome the limitations of conventional CDT by leveraging biological intelligence for precise cancer treatment.

Main Methods:

Constructed a DzMT nanoplatform via self-assembly of DNAzyme, metal ions (Fe2+/3+, Mn2+), and tannic acid.
Engineered the system for miRNA-triggered disassembly under acidic conditions, releasing therapeutic payloads.
Utilized tumor-specific miRNAs to activate DNAzyme, silence catalase mRNA, and promote H2O2 accumulation for Fenton reactions.

Main Results:

Achieved miRNA-activated DNAzyme for selective cancer imaging via fluorescence.
Demonstrated miRNA-directed gene silencing to increase intracellular H2O2 levels.
Established a self-sustaining Fenton cycle with tannic acid for continuous •OH generation and cancer cell eradication.
Showcased high-contrast tumor imaging and effective tumor growth suppression in vitro and in vivo.

Conclusions:

The developed DzMT nanoplatform enables precise, tumor-specific chemodynamic therapy regulated by intrinsic biological intelligence.
This approach offers a new paradigm for personalized anticancer therapy with enhanced safety and efficacy.