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Hyperbranched polysaccharides-From spatial structure to biological activity: A review.
Han Zhou1, Liping Wang1, Qin Wang2
1College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China.
International Journal of Biological Macromolecules
|April 22, 2026
Summary
Hyperbranched polysaccharides (HBPSs) show improved biological activities due to their unique structures. This review covers HBPS classification, modifications, and structure-activity relationships for optimized biofunctions.
Area of Science:
- Carbohydrate Chemistry
- Biochemistry
- Materials Science
Background:
- Linear polysaccharides have limited biological activities.
- Hyperbranched polysaccharides (HBPSs) possess unique architectures offering enhanced bioactivities.
- Understanding HBPS structure-activity relationships is crucial for developing novel biomaterials.
Purpose of the Study:
- To review the structural classification of HBPSs.
- To summarize modification strategies for enhancing HBPS bioactivities.
- To explore the structure-activity relationships and biological functions of HBPSs.
Main Methods:
- Literature review of HBPS structural classification.
- Analysis of chemical and enzymatic modification strategies.
- Examination of structure-activity relationships, focusing on branching parameters and conformation.
- Review of recent advances in HBPS biological functions.
Main Results:
- HBPSs exhibit diverse conformations (dendritic, spherical, comb-like) linked to function.
- Modifications significantly enhance HBPS bioactivities.
- Branched architecture, conformation, and branching degree critically affect cellular interactions.
Conclusions:
- HBPSs offer superior biological activities compared to linear counterparts.
- Structural features and modifications are key to optimizing HBPS functions.
- Further research can guide rational design for advanced HBPS applications.
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