Related Experiment Video
Updated: Sep 21, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
Fulminant Lupus Myocarditis as the Initial Manifestation of Systemic Lupus Erythematosus Successfully Treated with
Eri Morita1, Kenji Harada1, Takeshi Fujiwara1
1Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Japan.
Abstract:
Lupus myocarditis (LM) is a rare but potentially life-threatening manifestation of systemic lupus erythematosus. We report the case of a 36-year-old woman who presented with fulminant heart failure refractory to standard therapy. Concomitant nephrotic syndrome, hypocomplementemia, and positive anti-double-stranded DNA antibodies supported the diagnosis of LM. Given her rapid hemodynamic deterioration, high-dose intravenous steroid therapy was promptly initiated, leading to a rapid recovery of her cardiac function without mechanical circulatory support. An endomyocardial biopsy demonstrated mononuclear inflammatory cell infiltration and mild fibrosis, consistent with LM, with prominent tenascin-C deposition.
Related Concept Videos
Myocarditis I: Introduction
Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis III: Medical Management
Myocarditis IV: Nursing Management
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Rheumatic Heart Disease III: Medical Management
