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The role of concentrated growth factor (CGF) in type 1 tympanoplasty

Belgin Tutar1, Güler Berkiten2, Cem Çelik3

  • 1Department of Otorhinolaryngology- Head and Neck Surgery, University of Health Sciences, Prof Dr. Cemil Tascıoğlu City Hospital, Türkiye Darulaceze Cad. No:25 Okmeydani - Sisli, Istanbul, Türkiye. belgintutar@gmail.com.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|April 23, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
CGFGraftTympanoplastyUnderlay

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...

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