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Updated: Apr 25, 2026
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Visible-Light-Induced Copper-Catalyzed Coupling Reaction of Aryl Halides with Phenols at Room Temperature
Xiantong Yao1, Qinghua Zhong1, Xin Yang1
1School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Abstract:
This work describes a visible-light-induced Ullmann C-O coupling between aryl halides and phenols at room temperature without an external photocatalyst. Preliminary mechanistic studies suggest that the in situ-formed LCu(I)-phenoxide complex functions as both a photosensitizer and an active catalyst. The synthetic utility of this photoinduced Ullmann-type coupling was demonstrated by a gram-scale reaction with maintained high yield and successful late-stage functionalization of pharmaceutically relevant compounds in good yields.
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