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Related Experiment Video

Updated: Apr 27, 2026

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

Published on: January 25, 2020

Multiscale evolution of the 3D genome.

Yizhuo Che¹, Stephen J Bush², Kai Ye³

¹School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi, China; MOE Key Lab for Intelligent Networks & Networks Security, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Trends in Genetics : TIG

|April 25, 2026

Summary

This summary is machine-generated.

Genome architecture evolves rapidly at the cellular level and diversifies across species. Convergent evolution shapes higher-order features, linking genome structure to organismal form and function.

Keywords:

3D genome evolution macrolevel microlevel

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Last Updated: Apr 27, 2026

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

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Area of Science:

Genomics
Evolutionary Biology
Cell Biology

Background:

The spatial organization of the genome is crucial for gene regulation and function.
Understanding the evolutionary dynamics of genome architecture across different scales remains a challenge.

Purpose of the Study:

To synthesize current research on 3D genome evolution from micro- and macro-evolutionary perspectives.
To propose a framework for understanding the relationship between genome architecture diversity and the evolution of form and function.

Main Methods:

Review of existing literature on 3D genome organization and evolution.
Comparative analysis of genome architecture across different timescales (cellular, interspecies, phylogenetic).

Main Results:

Genome architecture evolves rapidly at the cellular level (e.g., in cancer) due to mutations and epigenetic changes.
Architectural divergence between species is primarily driven by alterations in cis-regulatory elements.
Despite diversity, recurrent higher-order genome features have emerged through convergent evolution, reflecting common functional needs.

Conclusions:

A micro-to-macro framework can explain the diversity of genome architectures.
Genome architecture evolution is intrinsically linked to the evolution of organismal form and function.